On my Ubuntu desktop with 22.04.5 LTS, the Display scale/fractional scaling setting does not persist between reboots. I'm pretty sure this worked when I originally set up the workstation around the middle of last year, but some time ago it stopped working.
I'm using an Nvidia RTX 4070 graphics card and X11, but I have no idea where to start debugging the issue, or what could be causing it not to save.